Fluoxetine (Prozac) - Off-Label for Hot Flashes and Mood Changes

About

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) FDA-approved for depression, anxiety disorders, and other psychiatric conditions, but frequently prescribed off-label for managing hot flashes and mood changes during menopause, especially when hormone therapy is contraindicated.

Efficacy

Clinical trials show reduction in hot flash frequency by 30-50% compared to 20-30% with placebo; particularly effective for women experiencing concurrent mood symptoms

Targets Symptoms