Clonidine (Catapres) - Off-Label for Hot Flashes

About

Clonidine is an alpha-2 adrenergic agonist FDA-approved for hypertension but commonly prescribed off-label for management of hot flashes in women who cannot use hormone therapy. Available as oral tablets and transdermal patches.

Efficacy

Clinical trials suggest moderate efficacy with 30-55% reduction in hot flash frequency and severity compared to placebo

Targets Symptoms