Bupropion (Wellbutrin) - Off-Label for Menopausal Depression and Low Libido

About

Bupropion is an atypical antidepressant FDA-approved for depression and smoking cessation but often prescribed off-label for managing mood symptoms and low sexual desire during menopause, as it is less likely to cause sexual side effects compared to other antidepressants.

Efficacy

Limited clinical trial data specific to menopause; evidence suggests improvement in mood symptoms and may maintain or enhance sexual function compared to SSRIs that often worsen sexual function

Targets Symptoms